SLIT3 deficiency attenuates pressure overload–induced cardiac fibrosis and remodeling

In pulmonary hypertension and certain forms of congenital heart disease, ventricular pressure overload manifests at birth and is an obligate hemodynamic abnormality that stimulates myocardial fibrosis, which leads to ventricular dysfunction and poor clinical outcomes. Thus, an attractive strategy is...

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Publicado en:JCI Insight
Autores principales: Gong, Lianghui, Wang, Shuyun, Shen, Li, Liu, Catherine, Shenouda, Mena, Li, Baolei, Liu, Xiaoxiao, Shaw, John A., Wineman, Alan L., Yang, Yifeng, Xiong, Dingding, Eichmann, Anne, Evans, Sylvia M., Weiss, Stephen J., Si, Ming-Sing
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406261/
https://ncbi.nlm.nih.gov/pubmed/32644051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136852
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