SLIT3 deficiency attenuates pressure overload–induced cardiac fibrosis and remodeling

In pulmonary hypertension and certain forms of congenital heart disease, ventricular pressure overload manifests at birth and is an obligate hemodynamic abnormality that stimulates myocardial fibrosis, which leads to ventricular dysfunction and poor clinical outcomes. Thus, an attractive strategy is...

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Bibliografiska uppgifter
I publikationen:JCI Insight
Huvudupphovsmän: Gong, Lianghui, Wang, Shuyun, Shen, Li, Liu, Catherine, Shenouda, Mena, Li, Baolei, Liu, Xiaoxiao, Shaw, John A., Wineman, Alan L., Yang, Yifeng, Xiong, Dingding, Eichmann, Anne, Evans, Sylvia M., Weiss, Stephen J., Si, Ming-Sing
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406261/
https://ncbi.nlm.nih.gov/pubmed/32644051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136852
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