SLIT3 deficiency attenuates pressure overload–induced cardiac fibrosis and remodeling

In pulmonary hypertension and certain forms of congenital heart disease, ventricular pressure overload manifests at birth and is an obligate hemodynamic abnormality that stimulates myocardial fibrosis, which leads to ventricular dysfunction and poor clinical outcomes. Thus, an attractive strategy is...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gong, Lianghui, Wang, Shuyun, Shen, Li, Liu, Catherine, Shenouda, Mena, Li, Baolei, Liu, Xiaoxiao, Shaw, John A., Wineman, Alan L., Yang, Yifeng, Xiong, Dingding, Eichmann, Anne, Evans, Sylvia M., Weiss, Stephen J., Si, Ming-Sing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406261/
https://ncbi.nlm.nih.gov/pubmed/32644051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136852
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