Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes

In diabetic dyslipidemia, cholesterol accumulates in the plasma membrane, decreasing fluidity and thereby suppressing the ability of cells to transduce ligand-activated signaling pathways. Liver X receptors (LXRs) make up the main cellular mechanism by which intracellular cholesterol is regulated an...

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Gepubliceerd in:JCI Insight
Hoofdauteurs: Vieira, Cristiano P., Fortmann, Seth D., Hossain, Masroor, Longhini, Ana Leda, Hammer, Sandra S., Asare-Bediako, Bright, Crossman, David K., Sielski, Micheli S., Adu-Agyeiwaah, Yvonne, Dupont, Mariana, Floyd, Jason L., Li Calzi, Sergio, Lydic, Todd, Welner, Robert S., Blanchard, Gary J., Busik, Julia V., Grant, Maria B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406260/
https://ncbi.nlm.nih.gov/pubmed/32641586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137230
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