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Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes
In diabetic dyslipidemia, cholesterol accumulates in the plasma membrane, decreasing fluidity and thereby suppressing the ability of cells to transduce ligand-activated signaling pathways. Liver X receptors (LXRs) make up the main cellular mechanism by which intracellular cholesterol is regulated an...
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| Gepubliceerd in: | JCI Insight |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7406260/ https://ncbi.nlm.nih.gov/pubmed/32641586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137230 |
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