Fasting and fasting mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction

AIMS/HYPOTHESIS: Homo Sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic stress, and tissue repair. Constant high energy-density food availability in present-d...

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Vydáno v:Diabetologia
Hlavní autoři: Hammer, Sandra S., Vieira, Cristiano P., McFarland, Delaney, Sandler, Maximilian, Levitsky, Yan, Dorweiler, Tim F., Lydic, Todd A., Asare-Bediako, Bright, Adu-Agyeiwaah, Yvonne, Sielski, Micheli S., Dupont, Mariana, Longhini, Ana Leda, Li Calzi, Sergio, Chakraborty, Dibyendu, Seigel, Gail M., Proshlyakov, Denis A., Grant, Maria B., Busik, Julia V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236268/
https://ncbi.nlm.nih.gov/pubmed/33770194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-021-05431-5
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