Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering

The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) “killer domains” of pro-apoptotic proteins in a surface groove, blocking apoptosi...

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Publicado no:Cell Chem Biol
Main Authors: Harvey, Edward P., Hauseman, Zachary J., Cohen, Daniel T., Rettenmaier, T. Justin, Lee, Susan, Huhn, Annissa J., Wales, Thomas E., Seo, Hyuk-Soo, Luccarelli, James, Newman, Catherine E., Guerra, Rachel M., Bird, Gregory H., Dhe-Paganon, Sirano, Engen, John R., Wells, James A., Walensky, Loren D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7405809/
https://ncbi.nlm.nih.gov/pubmed/32413285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.04.004
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