PINK1 phosphorylates Drp1(S616) to regulate mitophagy‐independent mitochondrial dynamics

Impairment of PINK1/parkin‐mediated mitophagy is currently proposed to be the molecular basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that PINK1 directly phosphorylates Drp1 on S616. Drp1(S616) phosphorylation is significantly reduced in cells and mouse tis...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:EMBO Rep
Huvudupphovsmän: Han, Hailong, Tan, Jieqiong, Wang, Ruoxi, Wan, Huida, He, Yaohui, Yan, Xinxiang, Guo, Jifeng, Gao, Qingtao, Li, Jie, Shang, Shuai, Chen, Fang, Tian, Runyi, Liu, Wen, Liao, Lujian, Tang, Beisha, Zhang, Zhuohua
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403662/
https://ncbi.nlm.nih.gov/pubmed/32484300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948686
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk