BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

Mutations in PINK1 (PTEN-induced putative kinase 1) cause early onset familial Parkinson's disease (PD). PINK1 accumulates on the outer membrane of damaged mitochondria followed by recruiting parkin to promote mitophagy. Here, we demonstrate that BCL2/adenovirus E1B 19-kDa interacting protein 3...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Zhang, Tongmei, Xue, Liang, Li, Li, Tang, Chengyuan, Wan, Zhengqing, Wang, Ruoxi, Tan, Jieqiong, Tan, Ya, Han, Hailong, Tian, Runyi, Billiar, Timothy R., Tao, W. Andy, Zhang, Zhuohua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076832/
https://ncbi.nlm.nih.gov/pubmed/27528605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733410
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