BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy

Mutations in PINK1 (PTEN-induced putative kinase 1) cause early onset familial Parkinson's disease (PD). PINK1 accumulates on the outer membrane of damaged mitochondria followed by recruiting parkin to promote mitophagy. Here, we demonstrate that BCL2/adenovirus E1B 19-kDa interacting protein 3...

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Foilsithe in:J Biol Chem
Main Authors: Zhang, Tongmei, Xue, Liang, Li, Li, Tang, Chengyuan, Wan, Zhengqing, Wang, Ruoxi, Tan, Jieqiong, Tan, Ya, Han, Hailong, Tian, Runyi, Billiar, Timothy R., Tao, W. Andy, Zhang, Zhuohua
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076832/
https://ncbi.nlm.nih.gov/pubmed/27528605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.733410
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