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Protrudin-mediated ER–endosome contact sites promote MT1-MMP exocytosis and cell invasion

Cancer cells break tissue barriers by use of small actin-rich membrane protrusions called invadopodia. Complete invadopodia maturation depends on protrusion outgrowth and the targeted delivery of the matrix metalloproteinase MT1-MMP via endosomal transport by mechanisms that are not known. Here, we...

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Vydáno v:J Cell Biol
Hlavní autoři: Pedersen, Nina Marie, Wenzel, Eva Maria, Wang, Ling, Antoine, Sandra, Chavrier, Philippe, Stenmark, Harald, Raiborg, Camilla
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401796/
https://ncbi.nlm.nih.gov/pubmed/32479595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202003063
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