ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1–matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In thi...

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Pubblicato in:J Cell Biol
Autori principali: Marchesin, Valentina, Castro-Castro, Antonio, Lodillinsky, Catalina, Castagnino, Alessia, Cyrta, Joanna, Bonsang-Kitzis, Hélène, Fuhrmann, Laetitia, Irondelle, Marie, Infante, Elvira, Montagnac, Guillaume, Reyal, Fabien, Vincent-Salomon, Anne, Chavrier, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2015
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621834/
https://ncbi.nlm.nih.gov/pubmed/26504170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201506002
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