The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4

The JNK-interacting proteins, JIP3 and JIP4, are specific effectors of the small GTP-binding protein ARF6. The interaction of ARF6–GTP with the second leucine zipper (LZII) domains of JIP3/JIP4 regulates the binding of JIPs to kinesin-1 and dynactin. Here, we report the crystal structure of ARF6–GTP...

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Détails bibliographiques
Auteurs principaux: Isabet, Tatiana, Montagnac, Guillaume, Regazzoni, Karine, Raynal, Bertrand, Khadali, Fatima El, England, Patrick, Franco, Michel, Chavrier, Philippe, Houdusse, Anne, Ménétrey, Julie
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750013/
https://ncbi.nlm.nih.gov/pubmed/19644450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.209
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