Switches in histone modifications epigenetically control vitamin D3-dependent transcriptional upregulation of the CYP24A1 gene in osteoblastic cells

In bone cells vitamin D dependent regulation of gene expression principally occurs through modulation of gene transcription. Binding of the active vitamin D metabolite 1,25(OH)(2)D(3) to the vitamin D receptor (VDR) induces conformational changes in its C-terminal domain enabling competency for inte...

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Udgivet i:J Cell Physiol
Main Authors: Moena, Daniel, Merino, Paola, Lian, Jane B., Stein, Gary S., Stein, Janet L., Montecino, Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401294/
https://ncbi.nlm.nih.gov/pubmed/31868234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.29420
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