Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B

Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional activation and repression of the Runx2 gene via its osteoblast-specific P1 promoter (encoding mRNA f...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rojas, Adriana, Aguilar, Rodrigo, Henriquez, Berta, Lian, Jane B., Stein, Janet L., Stein, Gary S., van Wijnen, Andre J., van Zundert, Brigitte, Allende, Miguel L., Montecino, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653688/
https://ncbi.nlm.nih.gov/pubmed/26453309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657825
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