ERK-mediated negative feedback regulation of oncogenic EGFRvIII in glioblastoma cells

Epidermal growth factor receptor variant III (EGFRvIII) is the most common active EGFR mutant in glioblastoma multiforme (GBM). The expression of this mutant often correlates with a poor patient prognosis due to its ability to extend downstream signaling. The EGFR pathway is controlled by a negative...

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Bibliografiske detaljer
Udgivet i:Oncol Lett
Main Authors: Haryuni, Ratna Dini, Tanaka, Tomohiro, Zhou, Yue, Yokoyama, Satoru, Sakurai, Hiroaki
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399944/
https://ncbi.nlm.nih.gov/pubmed/32782566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.11760
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