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LRIG1 negatively regulates the oncogenic EGF receptor mutant EGFRvIII

Epidermal growth factor receptor (EGFR) mutation is frequently observed in human cancer and contributes to the growth, survival and therapeutic resistance of tumors. EGFRvIII is an oncogenic EGFR mutant resulting from the deletion of exons 2–7 and is the most common EGFR mutant observed in glioblast...

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Autores principales: Stutz, MA, Shattuck, DL, Laederich, MB, Carraway, KL, Sweeney, C
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175812/
https://ncbi.nlm.nih.gov/pubmed/18542056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.185
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