Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat

Body weight is regulated by interoceptive neural circuits that track energy need, but how the activity of these circuits is altered in obesity remains poorly understood. Here we describe the in vivo dynamics of hunger-promoting AgRP neurons during the development of diet-induced obesity in mice. We...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Beutler, Lisa R, Corpuz, Timothy V, Ahn, Jamie S, Kosar, Seher, Song, Weimin, Chen, Yiming, Knight, Zachary A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398661/
https://ncbi.nlm.nih.gov/pubmed/32720646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55909
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