Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS

Excessive excitation is hypothesized to cause motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS), but actual proof of hyperexcitation in vivo is missing, and trials based on this concept have failed. We demonstrate, by in vivo single-MN electrophysiology, that, contrary to expectati...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Bączyk, Marcin, Alami, Najwa Ouali, Delestrée, Nicolas, Martinot, Clémence, Tang, Linyun, Commisso, Barbara, Bayer, David, Doisne, Nicolas, Frankel, Wayne, Manuel, Marin, Roselli, Francesco, Zytnicki, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398175/
https://ncbi.nlm.nih.gov/pubmed/32484501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191734
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