Synaptic restoration by cAMP/PKA drives activity-dependent neuroprotection to motoneurons in ALS

Excessive excitation is hypothesized to cause motoneuron (MN) degeneration in amyotrophic lateral sclerosis (ALS), but actual proof of hyperexcitation in vivo is missing, and trials based on this concept have failed. We demonstrate, by in vivo single-MN electrophysiology, that, contrary to expectati...

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Vydáno v:J Exp Med
Hlavní autoři: Bączyk, Marcin, Alami, Najwa Ouali, Delestrée, Nicolas, Martinot, Clémence, Tang, Linyun, Commisso, Barbara, Bayer, David, Doisne, Nicolas, Frankel, Wayne, Manuel, Marin, Roselli, Francesco, Zytnicki, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398175/
https://ncbi.nlm.nih.gov/pubmed/32484501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191734
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