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Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS), an adult onset disease in which there is progressive degeneration of motoneurones, it has been suggested that an intrinsic hyperexcitability of motoneurones (i.e. an increase in their firing rates), contributes to excitotoxicity and to disease onset. Here we s...

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Detalhes bibliográficos
Main Authors: Delestrée, Nicolas, Manuel, Marin, Iglesias, Caroline, Elbasiouny, Sherif M, Heckman, C J, Zytnicki, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979619/
https://ncbi.nlm.nih.gov/pubmed/24445319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2013.265843
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