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Early intrinsic hyperexcitability does not contribute to motoneuron degeneration in amyotrophic lateral sclerosis

In amyotrophic lateral sclerosis (ALS) the large motoneurons that innervate the fast-contracting muscle fibers (F-type motoneurons) are vulnerable and degenerate in adulthood. In contrast, the small motoneurons that innervate the slow-contracting fibers (S-type motoneurons) are resistant and do not...

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Publicat a:eLife
Autors principals: Leroy, Félix, Lamotte d'Incamps, Boris, Imhoff-Manuel, Rebecca D, Zytnicki, Daniel
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4227046/
https://ncbi.nlm.nih.gov/pubmed/25313866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04046
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