Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease

Lysosomal acid lipase (LAL) is a serine hydrolase that hydrolyzes cholesteryl ester (CE) and TGs delivered to the lysosomes into free cholesterol and fatty acids. LAL deficiency due to mutations in the LAL gene (LIPA) results in accumulation of TGs and cholesterol esters in various tissues of the bo...

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Bibliografski detalji
Izdano u:J Lipid Res
Glavni autori: Rajamohan, Francis, Reyes, Allan R., Tu, Meihua, Nedoma, Nicole L., Hoth, Lise R., Schwaid, Adam G., Kurumbail, Ravi G., Ward, Jessica, Han, Seungil
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2020
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397744/
https://ncbi.nlm.nih.gov/pubmed/32482718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000748
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