Lysosomal Acid Lipase Deficiency Impairs Regulation of ABCA1 Gene and Formation of High Density Lipoproteins in Cholesteryl Ester Storage Disease

ATP-binding cassette transporter A1 (ABCA1) mediates the rate-limiting step in high density lipoprotein (HDL) particle formation, and its expression is regulated primarily by oxysterol-dependent activation of liver X receptors. We previously reported that ABCA1 expression and HDL formation are impai...

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Bibliographic Details
Main Authors: Bowden, Kristin L., Bilbey, Nicolas J., Bilawchuk, Leanne M., Boadu, Emmanuel, Sidhu, Rohini, Ory, Daniel S., Du, Hong, Chan, Teddy, Francis, Gordon A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162423/
https://ncbi.nlm.nih.gov/pubmed/21757691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274381
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