Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease

Soluble oligomers of aggregated tau accompany the accumulation of insoluble amyloid fibrils, a histological hallmark of Alzheimer disease (AD) and two dozen related neurodegenerative diseases. Both oligomers and fibrils seed the spread of Tau pathology, and by virtue of their low molecular weight an...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Abskharon, Romany, Seidler, Paul M., Sawaya, Michael R., Cascio, Duilio, Yang, Tianxiao P., Philipp, Stephan, Williams, Christopher Kazu, Newell, Kathy L., Ghetti, Bernardino, DeTure, Michael A., Dickson, Dennis W., Vinters, Harry V., Felgner, Philip L., Nakajima, Rie, Glabe, Charles G., Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397112/
https://ncbi.nlm.nih.gov/pubmed/32493775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013638
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