Structure-based inhibitors halt prion-like seeding by Alzheimer's disease–and tauopathy–derived brain tissue samples

In Alzheimer's disease (AD) and tauopathies, tau aggregation accompanies progressive neurodegeneration. Aggregated tau appears to spread between adjacent neurons and adjacent brain regions by prion-like seeding. Hence, inhibitors of this seeding offer a possible route to managing tauopathies. H...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Seidler, Paul Matthew, Boyer, David R., Murray, Kevin A., Yang, Tianxiao P., Bentzel, Megan, Sawaya, Michael R., Rosenberg, Gregory, Cascio, Duilio, Williams, Christopher Kazu, Newell, Kathy L., Ghetti, Bernardino, DeTure, Michael A., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6827308/
https://ncbi.nlm.nih.gov/pubmed/31537646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009688
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