Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED

Electrons, because of their strong interaction with matter, produce high-resolution diffraction patterns from tiny 3D crystals only a few hundred nanometers thick in a frozen-hydrated state. This discovery offers the prospect of facile structure determination of complex biological macromolecules, wh...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sawaya, Michael R., Rodriguez, Jose, Cascio, Duilio, Collazo, Michael J., Shi, Dan, Reyes, Francis E., Hattne, Johan, Gonen, Tamir, Eisenberg, David S.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056061/
https://ncbi.nlm.nih.gov/pubmed/27647903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606287113
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