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Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases

Picornaviral RNA-dependent RNA polymerases (RdRPs) have low replication fidelity that is essential for viral fitness and evolution. Their global fold consists of the classical “cupped right hand” structure with palm, fingers, and thumb domains, and these RdRPs also possess a unique contact between t...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Watkins, Colleen L., Kempf, Brian J., Beaucourt, Stéphanie, Barton, David J., Peersen, Olve B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397104/
https://ncbi.nlm.nih.gov/pubmed/32493771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013906
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