CobT and BzaC catalyze the regiospecific activation and methylation of the 5-hydroxybenzimidazole lower ligand in anaerobic cobamide biosynthesis

Vitamin B(12) and other cobamides are essential cofactors required by many organisms and are synthesized by a subset of prokaryotes via distinct aerobic and anaerobic routes. The anaerobic biosynthesis of 5,6-dimethylbenzimidazole (DMB), the lower ligand of vitamin B(12), involves five reactions cat...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Mathur, Yamini, Sreyas, Sheryl, Datar, Prathamesh M., Sathian, Manjima B., Hazra, Amrita B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397103/
https://ncbi.nlm.nih.gov/pubmed/32503839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014197
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