TFAP2E Methylation and Expression Status Does Not Predict Response to 5FU-based Chemotherapy in Colorectal Cancer

PURPOSE: A recent study reported that 5-fluorouracil (5FU)-based chemotherapy is less effective in treating advanced colorectal cancer (CRC) patients demonstrating hypermethylation of TFAP2E gene. The aim of our study was to confirm and validate these findings in large, uniformly treated, well-chara...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Murcia, Oscar, Jover, Rodrigo, Egoavil, Cecilia, Perez-Carbonell, Lucia, Juárez, Miriam, Hernández-Illán, Eva, Rojas, Estefania, Alenda, Cristina, Balaguer, Francesc, Andreu, Montserrat, Llor, Xavier, Castells, Antoni, Boland, C. Richard, Goel, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396148/
https://ncbi.nlm.nih.gov/pubmed/29535127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2940
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