Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

OBJECTIVE: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype’s response to chemotherapy. DESIGN: This retrospective observat...

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Pubblicato in:PLoS One
Autori principali: Murcia, Oscar, Juárez, Míriam, Rodríguez-Soler, María, Hernández-Illán, Eva, Giner-Calabuig, Mar, Alustiza, Miren, Egoavil, Cecilia, Castillejo, Adela, Alenda, Cristina, Barberá, Víctor, Mangas-Sanjuan, Carolina, Yuste, Ana, Bujanda, Luís, Clofent, Joan, Andreu, Montserrat, Castells, Antoni, Llor, Xavier, Zapater, Pedro, Jover, Rodrigo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126803/
https://ncbi.nlm.nih.gov/pubmed/30188916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203051
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