Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans

There is a need for improved influenza vaccines. In this study we compared the antibody responses in humans after vaccination with an AS03-adjuvanted versus nonadjuvanted H5N1 avian influenza virus inactivated vaccine. Healthy young adults received two doses of either formulation 3 wk apart. We foun...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Proc Natl Acad Sci U S A
المؤلفون الرئيسيون: Ellebedy, Ali H., Nachbagauer, Raffael, Jackson, Katherine J. L., Dai, Ya-Nan, Han, Julianna, Alsoussi, Wafaa B., Davis, Carl W., Stadlbauer, Daniel, Rouphael, Nadine, Chromikova, Veronika, McCausland, Megan, Chang, Cathy Y., Cortese, Mario, Bower, Mary, Chennareddy, Chakravarthy, Schmitz, Aaron J., Zarnitsyna, Veronika I., Lai, Lilin, Rajabhathor, Arvind, Kazemian, Cheyann, Antia, Rustom, Mulligan, Mark J., Ward, Andrew B., Fremont, Daved H., Boyd, Scott D., Pulendran, Bali, Krammer, Florian, Ahmed, Rafi
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2020
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395544/
https://ncbi.nlm.nih.gov/pubmed/32661157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906613117
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