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Path Forward for RAF Therapies: Inhibition of Monomers and Dimers
Current BRAF inhibitors block signaling from monomeric BRAF(V600E), but not from oncogenic RAS, which requires RAF dimerization. In this issue of Cancer Cell, Yao and colleagues elucidate why current drugs are ineffective against RAF dimers, while Peng and coworkers describe a pan-RAF inhibitor targ...
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| Publicado no: | Cancer Cell |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7394233/ https://ncbi.nlm.nih.gov/pubmed/26373275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.08.006 |
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