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Targeting the Raf kinases in human cancer: the Raf dimer dilemma

The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the Ras GTPases and as the initiating kinases in the ERK cascade. In human cancer, Raf activity is frequently dysregulated due to mutations in the Raf family member B-Raf or to alteratio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Cancer
Egile Nagusiak: Durrant, David E, Morrison, Deborah K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5765234/
https://ncbi.nlm.nih.gov/pubmed/29235562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.399
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