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The importance of Raf dimerization in cell signaling

The Raf family of protein kinases are key signaling intermediates, acting as a central link between the membrane-bound Ras GTPases and the downstream kinases MEK and ERK. Raf kinase regulation is well-known for its complexity but only recently has it been realized that many of the mechanisms involve...

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Detalhes bibliográficos
Main Authors: Freeman, Alyson K, Ritt, Daniel A, Morrison, Deborah K
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976976/
https://ncbi.nlm.nih.gov/pubmed/23985533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.26117
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