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Raf Inhibitor-induced KSR1/B-Raf Binding and Its Effects on ERK Cascade Signaling

Raf kinase inhibitors can induce ERK cascade signaling by promoting dimerization of Raf family members in the presence of oncogenic or normally activated Ras [1–3]. This interaction is mediated by a dimer interface region in the Raf kinase domain that is conserved in members of the ERK cascade scaff...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McKay, Melissa M., Ritt, Daniel A., Morrison, Deborah K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075323/
https://ncbi.nlm.nih.gov/pubmed/21458265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.02.033
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