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Raf Inhibitor-induced KSR1/B-Raf Binding and Its Effects on ERK Cascade Signaling

Raf kinase inhibitors can induce ERK cascade signaling by promoting dimerization of Raf family members in the presence of oncogenic or normally activated Ras [1–3]. This interaction is mediated by a dimer interface region in the Raf kinase domain that is conserved in members of the ERK cascade scaff...

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Detalhes bibliográficos
Main Authors: McKay, Melissa M., Ritt, Daniel A., Morrison, Deborah K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075323/
https://ncbi.nlm.nih.gov/pubmed/21458265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.02.033
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