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Raf Inhibitor-induced KSR1/B-Raf Binding and Its Effects on ERK Cascade Signaling
Raf kinase inhibitors can induce ERK cascade signaling by promoting dimerization of Raf family members in the presence of oncogenic or normally activated Ras [1–3]. This interaction is mediated by a dimer interface region in the Raf kinase domain that is conserved in members of the ERK cascade scaff...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075323/ https://ncbi.nlm.nih.gov/pubmed/21458265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.02.033 |
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