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Inhibition of RAF dimers: it takes two to tango
The RAS-regulated RAF–MEK1/2–ERK1/2 pathway promotes cell proliferation and survival and RAS and BRAF proteins are commonly mutated in cancer. This has fuelled the development of small molecule kinase inhibitors including ATP-competitive RAF inhibitors. Type I and type I½ ATP-competitive RAF inhibit...
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| Publicado en: | Biochem Soc Trans |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Portland Press Ltd.
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7924995/ https://ncbi.nlm.nih.gov/pubmed/33367512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20200485 |
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