PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas

BACKGROUND: Glioma is the most common intrinsic brain tumor and also occurs in the spinal cord. Activating EGFR mutations are common in IDH1 wild-type gliomas. However, the cooperative partners of EGFR driving gliomagenesis remain poorly understood. RESULTS: We explore EGFR-mutant glioma evolution i...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Noorani, Imran, de la Rosa, Jorge, Choi, Yoonha, Strong, Alexander, Ponstingl, Hannes, Vijayabaskar, M. S., Lee, Jusung, Lee, Eunmin, Richard-Londt, Angela, Friedrich, Mathias, Furlanetto, Federica, Fuente, Rocio, Banerjee, Ruby, Yang, Fengtang, Law, Frances, Watts, Colin, Rad, Roland, Vassiliou, George, Kim, Jong Kyoung, Santarius, Thomas, Brandner, Sebastian, Bradley, Allan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392733/
https://ncbi.nlm.nih.gov/pubmed/32727536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02092-2
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