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Discovery and lead identification of quinazoline-based BRD4 inhibitors
A new series of quinazoline-based analogs as potent bromodomain-containing protein 4 (BRD4 inhibitors is described. The structure-activity relationships on 2- and 4-position of quinazoline ring, and the substitution at 6-position that mimic the acetylated lysine are discussed. A co-crystallized stru...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7392372/ https://ncbi.nlm.nih.gov/pubmed/30268702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.08.039 |
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