Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

Bacteria are known to evade β-lactam antibiotic action by producing β-lactamases (BLs), including carbapenemases, which are able to hydrolyze nearly all available β-lactams. The production of BLs represents one of the best known and most targeted mechanisms of resistance in bacteria. We have perform...

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Udgivet i:Sci Rep
Main Authors: Spyrakis, Francesca, Santucci, Matteo, Maso, Lorenzo, Cross, Simon, Gianquinto, Eleonora, Sannio, Filomena, Verdirosa, Federica, De Luca, Filomena, Docquier, Jean-Denis, Cendron, Laura, Tondi, Donatella, Venturelli, Alberto, Cruciani, Gabriele, Costi, Maria Paola
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391774/
https://ncbi.nlm.nih.gov/pubmed/32728062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69431-y
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