Structural effects of the highly protective V127 polymorphism on human prion protein

Prion diseases, a group of incurable, lethal neurodegenerative disorders of mammals including humans, are caused by prions, assemblies of misfolded host prion protein (PrP). A single point mutation (G127V) in human PrP prevents prion disease, however the structural basis for its protective effect re...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Hosszu, Laszlo L. P., Conners, Rebecca, Sangar, Daljit, Batchelor, Mark, Sawyer, Elizabeth B., Fisher, Stuart, Cliff, Matthew J., Hounslow, Andrea M., McAuley, Katherine, Leo Brady, R., Jackson, Graham S., Bieschke, Jan, Waltho, Jonathan P., Collinge, John
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391680/
https://ncbi.nlm.nih.gov/pubmed/32728168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01126-6
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