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Recombinant prion protein does not possess SOD-1 activity

A considerable body of evidence now shows that PrP (prion protein) binds metal ions with high affinity and it has been claimed that the binding of copper (II) ions to PrP confers SOD (superoxide dismutase) activity. In turn, it has been suggested that PrP is a synaptic dismutase and that loss of thi...

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Detalhes bibliográficos
Main Authors: Jones, Samantha, Batchelor, Mark, Bhelt, Daljit, Clarke, Anthony R., Collinge, John, Jackson, Graham S.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316266/
https://ncbi.nlm.nih.gov/pubmed/16156720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051236
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