A reassessment of copper(II) binding in the full-length prion protein

It has been shown previously that the unfolded N-terminal domain of the prion protein can bind up to six Cu(2+) ions in vitro. This domain contains four tandem repeats of the octapeptide sequence PHGGGWGQ, which, alongside the two histidine residues at positions 96 and 111, contribute to its Cu(2+)...

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Detalhes bibliográficos
Main Authors: Wells, Mark A., Jackson, Graham S., Jones, Samantha, Hosszu, Laszlo L. P., Craven, C. Jeremy, Clarke, Anthony R., Collinge, John, Waltho, Jonathan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615910/
https://ncbi.nlm.nih.gov/pubmed/16824036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060458
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