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Location and properties of metal-binding sites on the human prion protein

Although a functional role in copper binding has been suggested for the prion protein, evidence for binding at affinities characteristic of authentic metal-binding proteins has been lacking. By presentation of copper(II) ions in the presence of the weak chelator glycine, we have now characterized tw...

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Detalhes bibliográficos
Main Authors: Jackson, Graham S., Murray, Ian, Hosszu, Laszlo L. P., Gibbs, Nicholas, Waltho, Jonathan P., Clarke, Anthony R., Collinge, John
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC37470/
https://ncbi.nlm.nih.gov/pubmed/11438695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151038498
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