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Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site

ADP-ribosylhydrolase-like 1 (Adprhl1) is a pseudoenzyme expressed in the developing heart myocardium of all vertebrates. In the amphibian Xenopus laevis, knockdown of the two cardiac Adprhl1 protein species (40 and 23 kDa) causes failure of chamber outgrowth but this has only been demonstrated using...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Smith, Stuart J., Towers, Norma, Demetriou, Kim, Mohun, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7390403/
https://ncbi.nlm.nih.gov/pubmed/32726316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235433
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