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Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site

ADP-ribosylhydrolase-like 1 (Adprhl1) is a pseudoenzyme expressed in the developing heart myocardium of all vertebrates. In the amphibian Xenopus laevis, knockdown of the two cardiac Adprhl1 protein species (40 and 23 kDa) causes failure of chamber outgrowth but this has only been demonstrated using...

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Publicado en:PLoS One
Main Authors: Smith, Stuart J., Towers, Norma, Demetriou, Kim, Mohun, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7390403/
https://ncbi.nlm.nih.gov/pubmed/32726316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235433
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