Larger active site in an ancestral hydroxynitrile lyase increases catalytically promiscuous esterase activity

Hydroxynitrile lyases (HNL's) belonging to the α/β-hydrolase-fold superfamily evolved from esterases approximately 100 million years ago. Reconstruction of an ancestral hydroxynitrile lyase in the α/β-hydrolase fold superfamily yielded a catalytically active hydroxynitrile lyase, HNL1. Several...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jones, Bryan J., Evans, Robert L., Mylrea, Nathan J., Chaudhury, Debayan, Luo, Christine, Guan, Bo, Pierce, Colin T., Gordon, Wendy R., Wilmot, Carrie M., Kazlauskas, Romas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7326234/
https://ncbi.nlm.nih.gov/pubmed/32603354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235341
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