Catalytic promiscuity of ancestral esterases and hydroxynitrile lyases

Catalytic promiscuity is a useful, but accidental, enzyme property, so finding catalytically promiscuous enzymes in nature is inefficient. Some ancestral enzymes were branch points in the evolution of new enzymes and are hypothesized to have been promiscuous. To test the hypothesis that ancestral en...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Devamani, Titu, Rauwerdink, Alissa M., Lun-zer, Mark, Jones, Bryan J., Mooney, Joanna L., Tan, Maxilmilien Alaric O., Zhang, Zhi-Jun, Xu, Jian-He, Dean, Antony M., Kazlauskas, Romas J.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466365/
https://ncbi.nlm.nih.gov/pubmed/26736133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12209
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