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Catalytic promiscuity of ancestral esterases and hydroxynitrile lyases

Catalytic promiscuity is a useful, but accidental, enzyme property, so finding catalytically promiscuous enzymes in nature is inefficient. Some ancestral enzymes were branch points in the evolution of new enzymes and are hypothesized to have been promiscuous. To test the hypothesis that ancestral en...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Devamani, Titu, Rauwerdink, Alissa M., Lun-zer, Mark, Jones, Bryan J., Mooney, Joanna L., Tan, Maxilmilien Alaric O., Zhang, Zhi-Jun, Xu, Jian-He, Dean, Antony M., Kazlauskas, Romas J.
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466365/
https://ncbi.nlm.nih.gov/pubmed/26736133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12209
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