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Catalytic promiscuity of ancestral esterases and hydroxynitrile lyases

Catalytic promiscuity is a useful, but accidental, enzyme property, so finding catalytically promiscuous enzymes in nature is inefficient. Some ancestral enzymes were branch points in the evolution of new enzymes and are hypothesized to have been promiscuous. To test the hypothesis that ancestral en...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Devamani, Titu, Rauwerdink, Alissa M., Lun-zer, Mark, Jones, Bryan J., Mooney, Joanna L., Tan, Maxilmilien Alaric O., Zhang, Zhi-Jun, Xu, Jian-He, Dean, Antony M., Kazlauskas, Romas J.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466365/
https://ncbi.nlm.nih.gov/pubmed/26736133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b12209
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