BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

BACKGROUND: Identified as an Alzheimer’s disease (AD) susceptibility gene by genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central Nervous System (CNS). The distribution of these isoforms in different cell types, as well as their role in AD pathology still remains u...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Taga, Mariko, Petyuk, Vladislav A., White, Charles, Marsh, Galina, Ma, Yiyi, Klein, Hans-Ulrich, Connor, Sarah M., Kroshilina, Alexandra, Yung, Christina J., Khairallah, Anthony, Olah, Marta, Schneider, Julie, Karhohs, Kyle, Carpenter, Anne E., Ransohoff, Richard, Bennett, David A., Crotti, Andrea, Bradshaw, Elizabeth M., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7389646/
https://ncbi.nlm.nih.gov/pubmed/32727516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00387-3
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