Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

BACKGROUND: To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. METHODS: In three open-label, single-sequence, crossover studies, healthy Japanese males received single oral doses of esaxere...

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Vydáno v:BMC Pharmacol Toxicol
Hlavní autoři: Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7389645/
https://ncbi.nlm.nih.gov/pubmed/32727577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00423-4
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