Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects

AIMS: To investigate the effects of the strong cytochrome P450 (CYP) 3A inhibitor itraconazole and the strong CYP3A inducer rifampicin on the pharmacokinetics of single‐dose esaxerenone, a nonsteroidal mineralocorticoid receptor blocker, in healthy Japanese subjects. METHODS: Two open‐label, single‐...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495282/
https://ncbi.nlm.nih.gov/pubmed/32250463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14302
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