Pharmacokinetics and Safety of Single-Dose Esaxerenone in Japanese Subjects with Mild to Moderate Hepatic Impairment

INTRODUCTION: The mineralocorticoid receptor (MR) blocker esaxerenone is a new treatment for hypertension in Japan and under development for treatment of diabetic nephropathy. Hepatic impairment is known to impact the pharmacokinetics (PKs) of other MR blocking drugs. The aim of the present study wa...

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Detalhes bibliográficos
Publicado no:Adv Ther
Main Authors: Kurata, Akifumi, Yoshida, Takafumi, Inoue, Megumi, Ishizuka, Tomoko, Nakatsu, Takafumi, Shimizu, Takako, Kato, Manabu, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Healthcare 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979450/
https://ncbi.nlm.nih.gov/pubmed/31705436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-019-01121-2
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